Glenn, the completely blind Jack Russell, goes everywhere with his best friend and permanent guide Buzz, the Staffordshire bull terrier.
The pair were rescued from a sea tunnel in Hartlepool last month and are currently being cared for by the Stray Aid rescue centre in Coxhoe, County Durham.
Stray Aid said Buzz, 9, acts as a guide dog for Glenn, 10, and the centre wants to rehome the pair together so they can “live out their lives peacefully with as little change as possible”.
Sue Bielby told the BBC the dogs are inseparable and become upset when kept apart.
“Buzz acts as Glenn’s eyes and it’s as simple as that,” she told the broadcaster.
“Glenn gets his confidence from Buzz, and if they were separated even for a few minutes they both bark and become distressed, so they would need to have a loving home together.”
Buzz helps Glenn find his bed and food, even pushing him toward the right bowl if he’s eating from the wrong one, the Daily Mail quoted Stay Aid supervisor Diane Humphrey as saying.
The centre has said it will only consider rehousing the best friends together.
You can find out more about the work Stray Aid does here.